CYSTEINYL LEUKOTRIENES ARE IMPORTANT MEDIATORS OF AIRWAY INFLAMMATION AND ALLERGY SYMPTOMS6,7
Illustration is an artistic rendition Adapted from Howarth PH et al Allergy 2000;55 (suppl 64):7–16; Okuda M et al Ann Allergy 1988;60:537–540; Claesson H-E, Dahlén S-E J Int Med 1999;245:205–227; Dworski R et al Am J Respir Crit Care Med 1994;149:953–959.
DUAL PATHWAYS OF INFLAMMATION 10–12
Illustration is an artistic rendition
SINGULAIR inhibits the important leukotriene pathway of asthmatic inflammation8
Steroids do not block the formation of leukotrienes in the airways of asthmatics4,5,9,10
*
A study in 60 adult patients with allergic rhinitis to house dust. Nasal provocations with LTD4 (n=18), histamine (n=14), antigen (n=14), or control (n=14).3
**
Based on mean threshold concentration for nasal response.3
